PUBLICATIONS

1. Nagle A, Hur W, Gray NS: Antimitotic agents of natural origin. Curr Drug Targets. 2006, 7, (3), 305-26.

2. Liu Y, Gray NS: Rational design of inhibitors that bind to inactive kinase conformations. Nat Chem Biol. 2006, 2, (7), 358-64.

3. Okram B, Nagle A, Adrian FJ, Lee C, Ren P, Wang X, Sim T, Xie Y, Wang X, Xia G, Spraggon G, Warmuth M, Liu Y, Gray NS: A general strategy for creating “inactive-conformation” abl inhibitors. Chem Biol. 2006, 13, (7), 779-86.

4. Pan S, Mi Y, Pally C, Beerli C, Chen A, Guerini D, Hinterding K, Nuesslein-Hildesheim B, Tuntland T, Lefebvre S, Liu Y, Gao W, Chu A, Brinkmann V, Bruns C, Streiff M, Cannet C, Cooke N, Gray NS:A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. Chem Biol. 2006,13, (11),1227-34.

5. Galkin AV, Melnick JS, Kim S, Hood TL, Li N, Li L, Xia G, Steensma R, Chopiuk G, Jiang J, Wan Y, Ding P, Liu Y, Sun F, Schultz PG, Gray NS, Warmuth M: Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci USA. 2007, 104, (1), 270-5.

6. Melnick, J. S.; Janes, J.; Kim, S.; Chang, J. Y.; Sipes, D. G.; Gunderson, D.; Jarnes, L.; Matzen, J. T.; Garcia, M. E.; Hood, T. L.; Beigi, R.; Xia, G.; Harig, R. A.; Asatryan, H.; Yan, S. F.; Zhou, Y.; Gu, X. J.; Saadat, A.; Zhou, V.; King, F. J.; Shaw, C. M.; Su, A. I.; Downs, R.; Gray, N. S.; Schultz, P. G.; Warmuth, M.; Caldwell, J. S., An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A 2006.

7. Adrian FJ, Ding Q, Sim T, Velentza A, Sloan C, Liu Y, Zhang G, Hur W, Ding S, Manley P, Mestan J, Fabbro D, Gray NS*: Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006, 2(2): 95-102.

8. He Y*, Choi H S Wang, Z.; Richmond, W.; He, X.; Yang, K.; Jiang, T.; Sim, T.; Karanewsky, D.; Gu, X. J.; Zhou, V.; Liu, Y.; Ohmori O, Caldwell J, Gray N: Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 1. Bioorg Med Chem Lett. 2006.

9. Zhang Q, Liu Y, Gao F, Ding Q, Cho C, Hur W, Jin Y, Uno T, Joazeiro CA, Gray N*: Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library. J Am Chem Soc 2006, 128, (7), 2182-2183.

10. 38. Han S, Zhou V, Pan S, Liu Y, Hornsby M, McMullan D, Klock H E, Haugen J, Lesley S A, Gray N, Caldwell J, Gu XJ*: Identification of coumarin derivatives as a novel class of allosteric MEK1 inhibitors. Bioorg Med Chem Lett. 2005, 15, (24), 5467-73.

11. Bach S, Knockaert M, Reinhardt J, Lozach O, Schmitt S, Baratte B, Koken M, Coburn SP, Tang L, Jiang T, Liang DC, Galons H, Dierick JF, Pinna LA, Meggio F, Totzke F, Schachtele C, Lerman AS, Carnero A, Wan Y, Gray N, Meijer, L*: Roscovitine targets, protein kinases and pyridoxal kinase. J Biol Chem 2005, 280, (35), 31208-19.

12. Tang L, Li MH, Cao P, Wang F, Chang WR, Bach S, Reinhardt J, Ferandin Y, Galons H, Wan Y, Gray N, Meijer L, Jiang T, Liang DC*. Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives. J Biol Chem 2005, 280, (35), 31220-9.

13. Luesch H, Wu W, Ren P, Gray NS, Schultz PG, Supek F*: Genome-Wide Overexpression Screen in Yeast for Small Molecule Target Identification. Chemistry and Biology. 2005, 12(1): 55-63.

14. Li B, Liu Y, Uno T, Gray N*: Creating chemical diversity to target protein kinases. Comb Chem High Throughput Screen. 2004, 7(5): 453-72.

15. Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, Rosen H*: Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. J Biol Chem. 2004, 279(14): 13839-48.

16. Wan Y, Hur W, Cho CY, Liu Y, Adrian FJ, Lozach O, Bach S, Mayer T, Fabbro D, Meijer L, Gray NS*: Synthesis and target identification of hymenialdisine analogs. Chem Biol. 2004, 11(2): 247-59.

17. Wignall SM, Gray NS, Chang YT, Juarez L, Jacob R, Burlingame A, Schultz PG, Heald R: Identification of a novel protein regulating microtubule stability through a chemical approach. Chem Biol. 2004, 11(1): 135-46.

18. Wu X, Ding S, Ding Q, Gray NS, Schultz PG: Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc. 2004, 126(6): 1590-1.

19. Chao SH, Walker JR, Chanda SK, Gray NS, Caldwell JS: Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus. Mol Cell Biol. 2003, 23: 831-841.

20. Warmuth M, Damoiseaux R, Liu Y, Fabbro D, Gray N: SRC family kinases: potential targets for the treatment of human cancer and leukemia. Curr Pharm Des. 2003;9(25):2043-59. Review.

21. Ruetz S, Fabbro S, Zimmerman J, Meyer T, Gray N*: Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors. Current Med. Chem. Anti-Cancer Agents. 2003, 3: 1-14.

22. Knockaert M, Lenormand P, Gray N, Schultz P, Pouyssegur J, Meijer L: p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene. 2002, Sep 19; 21(42): 6413-24.

23. Wu X, Ding S, Ding Q, Gray NS, Schultz PG: A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc. 2002, 124: 14520-14521.

24. Chang YT, Choi G, Bae YS, Burdett M, Moon HS, Lee JW, Gray NS, Schultz PG, Meijer L, Chung SK, Choi KY, Suh PG, Ryu SH: Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem. 2002, 3: 897-901.

25. Ding S, Gray NS*, Ding Q, Wu X, Schultz PG*: Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines. J Comb Chem. 2002, 4: 183-186.

26. Ding S, Gray NS*, Wu X, Ding Q, Schultz PG*: A combinatorial scaffold approach toward kinase-directed heterocycle libraries. J Am Chem Soc. 2002, 124: 1594-1596.

27. Schang LM, Bantly A, Knockaert M, Shaheen F, Meijer L, Malim MH, Gray NS, Schaffer PA*: Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. J Virol. 2002, 76: 7874-7882.

28. Ding S, Gray NS*, Ding Q, Wu X, Schultz PG*: Expanding the Diversity of Purine Libraries. Tet. Lett. 2001, 42: 8751-8755.

29. Ding S, Gray NS*, Wu X, Ding Q, Schultz PG*: A Concise and Traceless Linker Strategy toward Combinatorial Libraries of 2,6,9-Substituted Purines. Org. Lett. 2001, 66(24): 8273-8276.

30. Chang YT, Wignall SM, Rosania GR, Gray NS, Hanson SR, Su AI, Merlie J, Jr., Moon HS, Sangankar SB, Perez O, Schultz P.G*: Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors. J Med Chem. 2001, 44: 4497-4500.

31. Harmse L, van Zyl R, Gray N, Schultz P, Leclerc S, Meijer L, Doerig C, Havlik I*: Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. Biochem Pharmacol. 2001, 62: 341-348.

32. Wu TY, Ding S, Gray NS*, Schultz PG*: Solid-phase synthesis of 2,3,5-trisubstituted indoles. Org Lett. 2001, 3: 3827-3830.

33. Verdugo DE, Cancilla MT, Ge X, Gray NS, Chang YT, Schultz PG, Negishi M, Leary JA, Bertozzi CR*: Discovery of estrogen sulfotransferase inhibitors from a purine library screen. J Med Chem. 2001, 44: 2683-2686.

34. Lin Q, Jiang F, Schultz PG, Gray NS*: Design of allele-specific protein methyltransferase inhibitors. J Am Chem Soc. 2001, 123: 11608-11613.

35. Ding S, Gray NS, Ding Q, Schultz PG*: A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines. J Org Chem. 2001, 66: 8273-8276.

36. Gray NS: Combinatorial libraries and biological discovery. Curr Opin Neurobiol. 2001, 11: 608-614.

37. Knockaert M, Gray NS, Damiens E, Chang YT, Grellier P, Grant K, Fergusson D, Mottram J, Soete M, Dubremetz JF, Le Roch K, Doerig C, Schultz PG, Meijer L*: Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilized inhibitors. Chemistry and Biology. 2000, 7(6): 411-22.

38. Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Shokat KM*: A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000, 407: 395-401.

39. Armstrong, Portley AR, Chang YT, Nierengarten DM, Cook BN, Bowman KG, Gray NS, Schultz PG, Bertozzi CR*: Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library. Angew Chem Int Ed Engl. 2000, 39(7): 1303-1306.

40. Gray NS, Detivaud L, Doerig C, Meijer L*: ATP-site directed inhibitors of cyclin-dependent kinases. Current Medicinal Chemistry. 1999, 6: 859-75. Review.

41. Chang YT, Gray NS, Rosania GR, Sutherlin DP, Kwon S, Norman TC, Sarohia R, Leost M, Meijer L, Schultz PG*: Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chemistry and Biology. 1999, 6: 361-375.

42. Rosania GR, Merlie Jr. J, Gray NS, Chang YT, Schultz PG, Heald R*: A Cyclin-dependent Kinase inhibitor inducing cancer cell differentiation: Biochemical identification using Xenopus egg extracts. Proc. Natl. Acad. Sci. USA. 1999, 96: 4794-4802.

43. Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG*: Exploiting Chemical Libraries, Structure, and Genomics in the Search for New Kinase Inhibitors. Science. 1998, 281: 533-538.

44. Brooks EE, Gray NS, Joly A, Kerwar SS, Lum RT, Mackman RL, Norman TC, Rosete J, Rowe M, Schow SR, Schultz PG, Wang X, Wick MM, Schiffman D*: CVT-313, A Specific and Potent Inhibitor of CDK2 that Prevents Neointimal Proliferation. J. Bio. Chem. 1997, 272: 29207-29211.

45. Gray NS, Kwon S, Schultz PG*: Combinatorial Synthesis of 2,9-Substituted Purines. Tetrahedron Lett. 1997, 38: 1161-1164.

46. Norman TN, Gray NS, Koh JT, Schultz PG*: A Structure-Based Approach to Kinase Inhibitors. J. Am. Chem. Soc. 1996, 118: 7430-7431.

47. Patten PA, Gray NS, Yang PL, Marks CB, Wedenmayer GJ, Boniface JJ, Stevens RC, Schultz PG*: The Immunological Evolution of Catalysis. Science. 1996, 271: 1086-1091.