RECENT PUBLICATIONS (Last updated 8/8/08)

Cichowski K, Hahn WC.
Unexpected pieces to the senescence puzzle.
Cell. 2008 Jun 13;133(6):958-61.
Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell MJ, Schnitt S, Polyak K.
Regulation of in situ to invasive breast carcinoma transition.
Cancer Cell. 2008 May;13(5):394-406.
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA.
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.
PLoS ONE. 2008 Apr 16;3(4):e2020.
Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L.
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
Cancer Cell. 2008 Apr;13(4):355-64.
Westermarck J, Hahn WC.
Multiple pathways regulated by the tumor suppressor PP2A in transformation.
Trends Mol Med. 2008 Apr;14(4):152-60.
Arroyo JD, Lee GM, Hahn WC.
Liprin alpha1 interacts with PP2A B56gamma.
Cell Cycle. 2008 Feb;7(4):525-32.
Lee J, Sung YH, Cheong C, Choi YS, Jeon HK, Sun W, Hahn WC, Ishikawa F, Lee HW.
TERT promotes cellular and organismal survival independently of telomerase activity.
Oncogene. 2008 Jan 28.
Schinzel AC, Hahn WC.
Oncogenic transformation and experimental models of human cancer.
Front Biosci. 2008 Jan 1;13:71-84.
Cho US, Morrone S, Sablina AA, Arroyo JD, Hahn WC, Xu W.
Structural basis of PP2A inhibition by small t antigen.
PLoS Biol. 2007 Aug;5(8):e202.
Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC.
Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
Cell. 2007 Jun 15;129(6):1065-79.
Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, Decaprio JA, Hahn WC.
The Tumor Suppressor PP2A Abeta Regulates the RalA GTPase.
Cell. 2007 Jun 1;129(5):969-982.
Park Y, Downing SR, Kim D, Hahn WC, Li C, Kantoff PW, Wei LJ.
Simultaneous and exact interval estimates for the contrast of two groups based on an extremely high dimensional variable: Application to Mass Spec data.
Bioinformatics. 2007 Apr 25; [Epub ahead of print].
Kim SY, Hahn WC.
Cancer Genomics: Integrating Form and Function.
Carcinogenesis. 2007 Apr 17 [Epub ahead of print].
Nieto M, Finn, S, Loda M, Hahn WC.
Prostate Cancer: Re-focusing on androgen receptor signaling.
Int J Biochem Cell Biol. Jan 20, 2007. [Epud ahead of print]
Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, Hahn WC, Virshup DM, Kornbluth S.
Role for the PP2A/B56delta Phosphatase in Regulating 14-3-3 Release from Cdc25 to Control Mitosis.
Cell. Nov 17;127(4):759-73, 2006.
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TR.
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
Cancer Cell. Oct;10(4):321-30, 2006.

Echeverri CJ, Breachy PA, Baum B, Boutros M, Buchholz F, Chanda SK, Downward J, Ellenberg J, Fraser AG, Hacohen N, Hahn WC, Jackson AL, Kiger A, Linsley PS, Lum L, Ma Y, Mathey-Prevot B, Root DE, Sabatini DM, Taipale J, Perrimon N, Bernards R.
Minimizing the risk of reporting false positives in large-scale RNAi screens.
Nat. Methods. Oct;3(10):777-9, 2006.
Root DE, Hacohen N, Hahn WC, Lander ES, Sabatini DM.
Genome-scale loss-of-function screening with a lentiviral RNAi library.
Nat. Methods. Sep;3(9):715-9, 2006.
Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA.
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Nature. Aug 17;442(7104):818-22, 2006. Epub 2006 Jul 16.
Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, Flotte TJ, Duncan LM, Granter SR, Chin L.
Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene.
Cell . Jun 30;125(7):1269-81, 2006.

Androgen-dependent regulation of her-2/neu in prostate cancer cells.

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum.

Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.
Cell. Mar 24;124(6):1283-98, 2006.
Polyak K, Hahn WC.
Roots and stems: stem cells in cancer.
Nat Med. Mar;12(3):296-300, 2006.
Arroyo JD, Hahn WC.
Involvement of PP2A in viral and cellular transformation.
Oncogene. Nov 21;24(52):7746-55, 2005.
Goessel G, Quante M, Hahn WC, Harada H, Heeg S, Suliman Y, Doebele M, von Werder A, Fulda C, Nakagawa H, Rustgi AK, Blum HE, Opitz OG.
Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis.
Proc Natl Acad Sci U S A. Oct 25;102(43):15599-604, 2005.
Yu EY, Hahn WC.
The origin of cancer.
Cancer Treat Res. 122:1-22, 2004.
Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M.
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
PLoS Med. Nov;2(11):e313, 2005.
Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC.
Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity.
Cancer Res. Sep 15;65(18):8183-92, 2005.
Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM.
The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.
Dev Cell. Sep;9(3):327-38, 2005.
Boehm JS, Hahn WC.
Cancer genetics: Finding the right mix.
Eur J Hum Genet. Oct;13(10):1099-100, 2005.
Boehm JS, Hession MT, Bulmer SE, Hahn WC.
Transformation of human and murine fibroblasts without viral oncoproteins.
Mol Cell Biol. Aug;25(15):6464-74, 2005.
Chen W, Arroyo JD, Timmons JC, Possemato R, Hahn WC.
Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity.
Cancer Res. Sep 15;65(18):8183-92, 2005.
Sjostrom SK, Finn G, Hahn WC, Rowitch DH, Kenney AM.
The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.
Dev Cell. Sep;9(3):327-38, 2005.
Boehm JS, Hahn WC.
Cancer genetics: Finding the right mix.
Eur J Hum Genet. Oct;13(10):1099-100, 2005.
Boehm JS, Hession MT, Bulmer SE, Hahn WC.
Transformation of human and murine fibroblasts without viral oncoproteins.
Mol Cell Biol. Aug;25(15):6464-74, 2005.
Possemato R, Hahn WC.
Contributions of telomerase to tumorigenesis.
In: Gewirtz D, Holt SE, ed. Apoptosis and senescence in cancer chemotherapy and radiotherapy.
Humana Press. In press.
Masutomi K, Hahn WC.
Telomerase.
In: Ganten D, Ruckpaul K, ed. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine.
Springer-Verlag. In press. (June 2006)
Masutomi K, Possemato R, Wong JMY, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC.
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Proc Natl Acad Sci. U.S.A. Jun 7;102(23):8222-7, 2005.
Nakamura M, Masutomi K, Kyo S, Hashimoto M, Maida Y, Kanaya T, Tanaka M, Hahn WC, Inoue M.
Efficient inhibition of hTERT expression by RNA interference causes a gradual decrease in cell proliferation and sensitizes cancer cells to ionizing radiation and chemotherapy.
Hum Gen Therapy. Jul;16(7):859-68, 2005.
Yu EY, Hahn WC.
Genetic alterations in prostate cancer.
Clin Prostate Cancer. 3(4):220-9, 2005.
Boehm JS, Hahn WC.
Understanding transformation: progress and gaps.
Curr Opin Genet Dev. 15(1):13-7, 2005.
Hahn WC.
Telomerase and telomerase dynamics in human cells.
Current Molecular Medicine. 5:29-38, 2005.
Dong CK, Masutomi K, Hahn WC.
Telomerase: regulation, function and transformation.
Crit Rev Oncol Hematol. 54(2):85-93, 2005.
Hashimoto M, Kyo S, Masutomi K, Maida Y, Sakaguchi J, Mizumoto Y, Nakamura M, Hahn WC,
Inoue M.
Analysis of telomeric single-strand overhang length in human endometrial cancers.
FEBS Lett. May 11, 2005.
Yu EY, Hahn WC.
The origin of cancer. In: Farid NR, ed. Molecular Basis of Thyroid Cancer.
Kluwer Academic Publisher. Chapter 1:1-22, 2004.
Satyanarayana A, Greenberg RA, Schaetzlein S, Buer J, Masutomi K, Hahn WC, Zimmermann S, Martens U, Manns MP, Rudolph KL.
Mitogen stimulation co-operates with telomere shortening to activeate DNA-damage responses and senescence signaling.
Mol. Cell Biol. 24:5459-5474, 2004.
Chiang YJ, Hemann MT, Hathcock KS, Hahn WC, Hodes RJ.
Expression of telomerase RNA template (mTR), but not telomerase reverse transcriptase (mTERT), is limiting for telomere length maintenance in vivo.
Mol. Cell Biol. 24:7024-31, 2004.
Moreno CS, Ramachandran S, Ashby DG, Laycock N, Plattner CA, Chen W, Hahn WC, Pallas DC.
Signaling and transcriptional changes critical for transformation of human cells by SV40 small tumor antigen or PP2A B56y knockdown.
Cancer Res. 64:6978-6988, 2004.
Hahn WC.
Cancer: surviving on the edge.
Cancer Cell. 6(3):215-22, 2004.
Zhao JJ, Roberts TM, Hahn WC.
Functional genetics and experimental models of human cancer.
Trends Mol Med. 10(7):344-50, 2004.
Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC.
Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.
Cancer Res. Dec 15;64(24):8867-75, 2004.
Boehm JS, Hahn WC.
Immortalized cells as experimental models to study cancer.
Cytotechology 45:47-59, 2004.
Vonderheide RH, Domchek SM, Schultze JL, George DJ, Hoar KM, Chen D-Y, Stephans KF, Masutomi K, Loda M, Xia Z, Anderson KS, Hahn WC, Nadler LM.
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
Clin Cancer Res. 10:828-839, 2004.
Yu EY, Hahn WC, George DJ, Kantoff PW.
Opportunities for targeted molecular therapy. In: Klen EA, ed. Management of prostate cancer.
Totowa: Humana Press. Chapter 35:631-652, 2004.
Hahn WC.
New functions for telomerase.
Cancer Research and Treatment. 35:467-471, 2004.
Khurts S, Masutomi K, Delgermaa L, Arai K, Oishi N, Mizuno H, Hayashi N, Hahn WC, Murakami S.
Nucleolin interacts with telomerase.
J. Biol. Chem. 279:51508-15, 2004.
Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, Counter CM, Nevins JR, Means AR, Sears R.
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Nat Cell Biol. 6(4):308-18, 2004.
Hahn WC.
Experimental Models of Human Cancer.
Cell Cycle. 3:604-5, 2004.
Hahn WC.
Targeting cancer with telomerase: commentary re Q. Huang et al., a novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells.
Clin. Cancer Res., 10: 1439-1445, 2004.
Clin Cancer Res. 10(4):1203-5, 2004. No abstract available.
Vonderheide RH, Domchek SM, Schultze JL, George DJ, Hoar KM, Chen DY, Stephans KF, Masutomi K, Loda M, Xia Z, Anderson KS, Hahn WC, Nadler LM.
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.
Clin Cancer Res. 10(3):828-39, 2004.
Baykal A, Thompson JA, Xu XC, Hahn WC, Deavers MT, Malpica A, Gershenson DM, Silva EG, Liu J.
In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues.
Oncol Rep. 11(2):297-302, 2004.
Liu J, Yang G, Thompson-Lanza JA, Glassman A, Hayes K, Patterson A, Marquez RT, Auersperg N, Yu Y, Hahn WC, Mills GB, Bast, RC Jr.
A genetically defined model for human ovarian cancer.
Cancer Res. 64(5):1655-63, 2004.
*Chen W, *Possemato R, Campbell KT, Plattner CA, Pallas DC, Hahn WC.
Identification of specific PP2A complexes involved in human cell transformation.
Cancer Cell. 5(2):127-36, 2004. *These authors contributed equally to this work.
Masutomi K, Hahn WC.
Telomerase expression: only half the story.
Cancer Biol Ther. 2(6):685-6, 2003.
Masutomi K, *Yu EY, *Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC.
Telomerase maintains telomere structure in normal human cells.
Cell. 114(2):241-53, 2003. *These authors contributed equally to this work.
Blasco MA, Hahn WC.
Evolving views of telomerase and cancer.
Trends Cell Biol. 13(6):289-94, 2003.
Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC.
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase.
Cancer Cell. 3(5):483-95, 2003.
Masutomi K, Hahn WC.
Telomerase and tumorigenesis.
Cancer Lett. 194(2):163-72, 2003.
Stewart SA, Ben-Porath I, Carey VJ, O'Connor BF, Hahn WC, Weinberg RA.
Erosion of the telomeric single-strand overhang at replicative senescence.
Nat Genet. 33(4):492-6, 2003.
Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD.
Lentivirus-delivered stable gene silencing by RNAi in primary cells.
RNA. 9(4):493-501, 2003.
Irwin MS, Kondo K, Marin MC, Cheng LS, Hahn WC, Kaelin WG.
Chemosensitivity linked to p73 function.
Cancer Cell. 3(4):403-10, 2003.
Dolma S, Lessnick SL, Hahn WC, Stockwell BR.
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells.
Cancer Cell. 3(3):285-96, 2003.
Hahn WC.
Role of telomeres and telomerase in the pathogenesis of human cancer.
J Clin Oncol. 21(10):2034-43, 2003.
Chen W, Hahn WC.
SV40 Early Region oncoproteins and human cell transformation.
Histol Histopathol. 18(2):541-50, 2003.
Wei W, Jobling W, Chen W, Hahn WC, Sedivy JM.
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts.
Mol Cell Biol. 23(8):2859-70, 2003.
*Stewart SA, *Dykxhoorn DM, *Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen ISY, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells.
*These authors contributed equally to this work. Supplementary data.
RNA. 9(4):493-501, 2003.
Vonderheide RH, Hahn WC.
Potential of the telomerase catalytic subunit as a universal tumor-associated antigen for cancer immunotherapy. In G. Krupp and R. Parwareshch, ed., Telomerases, Telomeres and Cancer.
Georgetown, TX: RG Landes Co. Vol 22, Chapter 10, 114-120, 2002.
Hahn, WC.
Empty pockets yield more telomere change.
Cell Cycle. 1(6):406-7, 2002.
Weijzen S, Rizzo P, Braid M, Vaishnav R, Jonkheer SM, Zlobin A, Osborne BA, Gottipati S, Aster JC, Hahn WC, Rudolf M, Siziopikou K, Kast WM, Miele L.
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells.
Nat Med. 8(9):979-86, 2002.
Hahn WC.
Senescence, telomere shortening and telomere maintenance.
Cancer Biol Ther. 1(4):398-400, 2002.
Hahn WC, Weinberg RA.
Rules for making human tumor cells
N Engl J Med. 347(20):1593-603, 2002.
Stewart SA, Hahn WC, O'Connor BF, Banner EN, Lundberg AS, Modha P, Mizuno H, Brooks MW, Fleming MD, Zimonjic DB, Popescu NC, Weinberg RA.
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism.
Proc Natl Acad Sci U S A . 99(20):12606-11, 2002.
Hahn WC, Weinberg RA.
Modelling the molecular circuitry of cancer.
Nat Rev Cancer. 2(5):331-41, 2002.
Hahn WC.
Immortalization and transformation of human cells.
Mol Cells. 30;13(3):351-61, 2002.
Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricala C, O'Toole KM.
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol Cell Biol. 22(14):5157-72, 2002.
Lundberg AS, Randell SH, Stewart SA, Elenbaas B, Hartwell KA, Brooks MW, Fleming MD, Olsen JC, Miller SW, Weinberg RA, Hahn WC.
Immortalization and transformation of primary human airway epithelial cells by gene transfer.
Oncogene. 4;21(29):4577-86, 2002.
Stewart SA, Hahn WC.
Prospects for anti-neoplastic therapies based on telomere biology.
Current Cancer Drug Targets. 2:1-17, 2002.
Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA.
Enumeration of the SV40 Early Region elements necessary for human cell transformation.
Mol. Cel. Biol. 22:2111-2123, 2002.
Zimonjic D, Brooks MW, Popescu N, Weinberg RA, Hahn WC.
Derivation of human tumor cells in vitro without genomic instability.
Cancer Res. 61:8838-8844, 2001.
Vonderheide RH, Anderson KS, Hahn WC, Butler MO, Schultze JL, Nadler LM.
Characterization of HLA-A3-restricted cytotoxic T lymphocytes reactive against the widely expressed tumor antigen telomerase.
Clin Cancer Res. 7:3343-3348, 2001.
Vonderheide RH, Schultze JL, Anderson KS, Maecker B, Butler MO, Xia Z, Kuroda MJ, von Bergwelt-Baildon MS, Bedor MM, Hoar KM, Schnipper DR, Brooks MW, Letvin NL, Stephans KF, Wucherpfennig KW, Hahn WC, Nadler LM.
Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals.
61:8366-8370, 2001.
Hahn WC.
Telomerase and Cancer: Where and when?
Clin. Cancer Res. 7: 2953-2954, 2001.
Opitz OG, Suliman Y, Hahn WC, Blum HE, Rustgi AK.
Cyclin D1 overexpression and p53 inactivation immortalizes primary oral keratinocytes by a telomerase independent mechanism.
J Clin Invest. 108:725-732, 2001.
Hahn WC, Meyerson M.
Telomerase Activation, Cellular Immortalization, and Cancer.
Ann. Med. 33:123-129, 2001.
Johnson FB, Marciniak RA, McVey M, Stewart SA, Hahn WC, Guarente L.
The S. cerevisiae WRN homologue Sgs1p participates in telomere maintenance in cells lacking telomerase.
EMBO J. 20:905-913, 2001.
Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Liu Donaher J, Popescu NC, Hahn WC, Weinberg RA.
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
Genes Dev. 15:50-65, 2001.
Lundberg AS, Hahn WC, Gupta P, Weinberg RA.
Genes involved in senescence and immortalization.
Curr Opin Cell Biol. 12:705-709, 2000.
Dickson MA, Hahn WC, Ino Y, Ronfard V, Wu JY, Louis DN, Weinberg RA, Li FP, Rheinwald JG.
Human keratinocytes that express hTERT and also evade a p16ink4a-enforced lifespan limit become immortal while retaining normal growth and differentiation characteristics.
Mol. Cell. Bio. 20:1436-1447, 2000.
Vonderheide RH, Hahn WC, Schultze J, Nadler LM.
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes.
Immunity. 10:673-679, 1999.
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA.
Creation of human tumor cells with defined genetic elements.
Nature. 400:464-468, 1999.
Hahn WC, Stewart SA, Brooks MW, York SG, Ng-Eaton E, Kurachi A, Beijersbergen RL, Knoll JHM, Meyerson M, Weinberg RA.
Inhibition of telomerase limits the growth of human cancer cells.
Nature Medicine. 5:1164-1170, 1999.
Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA.
Dissociation among in vitro telomerase activity, telomere maintenance and cellular immortalization.
Proc. Natl. Acad. Sci. U.S.A. 95:14723-14728, 1998.