This table shows the results of pair
wise comparisons of different T-ALL groups HOX11, TAL1, LYL1 and NO-ONCOGENE
(this group contains those cases without detectable misexpression of TAL1,
LYL1 or HOX11 and two cases with simultaneous expression both TAL1 and
LYL1 oncogenes). Genes with Permax P values <0.3 were selected to construct
the hierarchical clustering of T-ALL samples shown in figure 4.
| TAL1 high HOX11 low | P | HOX11 high TAL1 low | P | LYL1 high HOX11 low | 0 | NO-ONCOGENE_GROUP high HOX11 low | 0 | ||||
| U89922 | 0.006 | LTB Lymphotoxin-beta | S38742 | 0 | HOX11 Homeo box 11 (T-cell lymphoma 3-associated breakpoint) | M14745 | 0.002 | BCL2 B cell lymphoma protein 2 | X14448 | O.49 | ALPHA-GALACTOSIDASE A PRECURSOR |
| M12959 | 0.008 | TCRA T cell receptor alpha-chain | M13194 | 0.007 | ERCC1 Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | S53911 | 0.002 | CD34 CD34 antigen (hemopoietic progenitor cell antigen) | NO-ONCOGENE high TAL1 low | 0 | |
| U09770 | 0.012 | Cysteine-rich heart protein (hCRHP) mRNA | U30521 | 0.007 | FRAP FK506 binding protein 12-rapamycin associated protein | S77763 | 0.002 | NF-E2 protein (NF-E2) mRNA | U79260 | 0.075 | Clone 23745 mRNA |
| U51240 | 0.013 | KIAA0085 gene, partial cds | M28826 | 0.02 | CD1B CD1b antigen (thymocyte antigen) | Z68228 | 0.008 | JUP Junction plakoglobin | U30521 | 0.206 | FRAP FK506 binding protein 12-rapamycin associated protein |
| U23852 | 0.038 | T-lymphocyte specific protein tyrosine kinase p56lck (lck) abberant mRNA | U79260 | 0.05 | Clone 23745 mRNA | D50915 | 0.012 | KIAA0125 gene | D00749 | 0.257 | T-CELL ANTIGEN CD7 PRECURSOR |
| U43185 | 0.064 | STAT5A Signal transducer and activator of transcription 5A | M28825 | 0.06 | CD1A CD1a antigen (thymocyte antigen) | X52192 | 0.036 | FES Feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog | U45982 | 0.268 | G protein-coupled receptor GPR-9-6 gene |
| X62055 | 0.1 | PTPN6 Protein tyrosine phosphatase, non-receptor type 6 | M27749 | 0.076 | Immunoglobulin-related 14.1 protein mRNA | M91438 | 0.054 | Kazal-type serine proteinase (HUSI-II) gene | HG4312-HT4582 | 0.468 | Transcription Factor Iiia |
| X60992 | 0.145 | T-CELL DIFFERENTIATION ANTIGEN CD6 PRECURSOR | U70323 | 0.099 | SCA2 Spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant) | U51240 | 0.07 | KIAA0085 gene, partial cds | NO-ONCOGENE high LYL1 low | 0 | |
| J05243 | 0.156 | SPTAN1 Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | U33822 | 0.112 | Tax1-binding protein TXBP181 mRNA | M22638 | 0.134 | LYL-1 protein gene | M69181 | 0.001 | Nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds |
| X62466 | 0.158 | CDW52 CDW52 antigen (CAMPATH-1 antigen) | Y00815 | 0.255 | PTPRF Protein tyrosine phosphatase, receptor type, f polypeptide | X61118 | 0.15 | Description for X61118 (clusters Hs.78822 Hs.100012) not available | X62535 | 0.117 | DAGK1 Diacylglycerol kinase, alpha (80kD) |
| Y11215 | 0.159 | SKAP55 protein | M94250 | 0.304 | MDK Midkine (neurite growth-promoting factor 2) | X72889 | 0.162 | Transcriptional activator hSNF2a | D86479 | 0.253 | Non-lens beta gamma-crystallin like protein (AIM1) mRNA, partial cds |
| Y00796 | 0.207 | ITGAL Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | X58521 | 0.403 | NUCLEAR PORE GLYCOPROTEIN P62 | S82470 | 0.164 | BB1 | J03077 | 0.374 | PSAP Sulfated glycoprotein 1 |
| J03077 | 0.214 | PSAP Sulfated glycoprotein 1 | X75304 | 0.434 | Golgi antigen gcp372 | M33552 | 0.166 | Lymphocyte-specific protein 1 (LSP1) mRNA | |||
| L25931 | 0.231 | LBR Lamin B receptor | L17131 | 0.487 | HMGIY High mobility group (nonhistone chromosomal) protein isoforms I and Y | D87460 | 0.242 | KIAA0270 gene, partial cds | |||
| M80244 | 0.237 | INTEGRAL MEMBRANE PROTEIN E16 | HOX11 high LYL1 low | P | HG3521-HT3715 | 0.269 | Ras-Related Protein Rap1b | ||||
| X16064 | 0.237 | TRANSLATIONALLY CONTROLLED TUMOR PROTEIN | M28826 | 0.003 | CD1B CD1b antigen (thymocyte antigen) | U28014 | 0.282 | ICH-2 PROTEASE PRECURSOR | |||
| U13991 | 0.251 | TATA-binding protein associated factor 30 kDa subunit (tafII30) mRNA | AB001325 | 0.013 | AQP3 Aquaporin 3 | U67963 | 0.327 | Lysophospholipase homolog (HU-K5) mRNA | |||
| D43968 | 0.261 | CBFA2 Proto-oncogene AML1 {alternative products} | S38742 | 0.023 | HOX11 Homeo box 11 (T-cell lymphoma 3-associated breakpoint) | M13241 | 0.339 | N-MYC PROTO-ONCOGENE PROTEIN | |||
| K02777 | 0.286 | T-cell receptor active alpha-chain mRNA from Jurkat cell line | X66945 | 0.142 | FGFR1 Basic fibroblast growth factor (bFGF) receptor (shorter form) | X87212 | 0.348 | CTSC Cathepsin C | |||
| J04182 | 0.297 | LAMP1 Lysosome-associated membrane protein 1 | U21090 | 0.335 | DNA polymerase delta small subunit mRNA | D83735 | 0.372 | Adult heart mRNA for neutral calponin | |||
| U89336 | 0.304 | Description for U89336 (clusters Hs.184 Hs.5205 Hs.6587 Hs.34606 Hs.79985 Hs.81737 Hs.96387) not available | X78136 | 0.38 | HnRNP-E2 mRNA | U19713 | 0.372 | Allograft inflammatory factor-1 (AIF-1) mRNA | |||
| X16832 | 0.305 | CTSH Cathepsin H | L40386 | 0.389 | DP2 (Humdp2) mRNA | M38449 | 0.382 | Transforming growth factor-beta mRNA, clone pTGF-beta-trp114 | |||
| U37146 | 0.308 | Silencing mediator of retinoid and thyroid hormone action (SMRT) mRNA | M69181 | 0.439 | Nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds | L13738 | 0.391 | Activated p21cdc42Hs kinase (ack) mRNA | |||
| M23323 | 0.31 | T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN PRECURSOR | U73379 | 0.456 | Cyclin-selective ubiquitin carrier protein mRNA | Y00433 | 0.438 | GPX1 Glutathione peroxidase 1 | |||
| D11086 | 0.362 | IL2RG Interleukin 2 receptor gamma chain | U93049 | 0.46 | SLP-76 associated protein mRNA | D13370 | 0.492 | DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE | |||
| U86070 | 0.408 | PMM1 Phosphomannomutase | M92287 | 0.463 | CCND3 Cyclin D3 | LYL1 high TAL1 low | 0 | ||||
| D83735 | 0.449 | Adult heart mRNA for neutral calponin | U33822 | 0.471 | Tax1-binding protein TXBP181 mRNA | M14745 | 0 | BCL2 B cell lymphoma protein 2 | |||
| L76200 | 0.449 | Guanylate kinase (GUK1) mRNA | HOX11 high NO-ONCOGENE_GROUP low | P | D50915 | 0.001 | KIAA0125 gene | ||||
| Z69043 | 0.482 | mRNA translocon-associated protein delta subunit precursor | S38742 | 0.002 | HOX11 Homeo box 11 (T-cell lymphoma 3-associated breakpoint) | M22638 | 0.001 | LYL-1 protein gene | |||
| U65785 | 0.488 | 150 kDa oxygen-regulated protein ORP150 mRNA | M80397 | 0.353 | POLD1 Polymerase (DNA directed), delta 1, catalytic subunit (125kD) | X52192 | 0.005 | FES Feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog | |||
| X57398 | 0.488 | NME1 Non-metastatic cells 1, protein (NM23A) expressed in | HG919-HT919 | 0.418 | Dna Polymerase, Epsilon, Catalytic Subunit | U67963 | 0.014 | Lysophospholipase homolog (HU-K5) mRNA | |||
| TAL1 high LYL1 low | P | M15205 | 0.484 | TK1 Thymidine kinase 1, soluble | X61118 | 0.038 | Description for X61118 (clusters Hs.78822 Hs.100012) not available | ||||
| M16336 | 0.003 | CD2 CD2 antigen (p50), sheep red blood cell receptor | M91438 | 0.04 | Kazal-type serine proteinase (HUSI-II) gene | ||||||
| U23852 | 0.011 | T-lymphocyte specific protein tyrosine kinase p56lck (lck) abberant mRNA | M27749 | 0.081 | Immunoglobulin-related 14.1 protein mRNA | ||||||
| J03077 | 0.02 | PSAP Sulfated glycoprotein 2 | M13241 | 0.097 | N-MYC PROTO-ONCOGENE PROTEIN | ||||||
| L76200 | 0.046 | Guanylate kinase (GUK1) mRNA | U38847 | 0.116 | TAR RNA loop binding protein (TRP-185) mRNA | ||||||
| S78187 | 0.051 | M-PHASE INDUCER PHOSPHATASE 2 | U70027 | 0.125 | Description for U78027 (clusters Hs.3136 Hs.15593 Hs.85020) not available | ||||||
| J05243 | 0.052 | SPTAN1 Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) | S77763 | 0.175 | NF-E2 protein (NF-E2) mRNA | ||||||
| M92287 | 0.072 | CCND3 Cyclin D3 | X72889 | 0.187 | Transcriptional activator hSNF2a | ||||||
| X76223 | 0.072 | MAL gene exon 4 | HG987-HT987 | 0.202 | Mac25 | ||||||
| U37146 | 0.103 | Silencing mediator of retinoid and thyroid hormone action (SMRT) mRNA | D88270 | 0.218 | Immunoglobulin lambda gene locus DNA, clone:123E1 | ||||||
| X59871 | 0.108 | TCF7 Transcription factor 7 (T-cell specific) | S53911 | 0.247 | CD34 CD34 antigen (hemopoietic progenitor cell antigen) | ||||||
| M33197 | 0.188 | GAPDH | S82470 | 0.305 | BB1 | ||||||
| X62535 | 0.223 | DAGK1 Diacylglycerol kinase, alpha (80kD) | Z68228 | 0.32 | JUP Junction plakoglobin | ||||||
| U86070 | 0.228 | PMM1 Phosphomannomutase | U60975 | 0.336 | Hybrid receptor gp250 precursor mRNA | ||||||
| J04823 | 0.248 | CYTOCHROME C OXIDASE POLYPEPTIDE VIII-LIVER/HEART PRECURSOR | L13738 | 0.353 | Activated p21cdc42Hs kinase (ack) mRNA | ||||||
| X60992 | 0.248 | T-CELL DIFFERENTIATION ANTIGEN CD6 PRECURSOR | Y12670 | 0.388 | LEPR Leptin receptor | ||||||
| X62534 | 0.253 | HMG2 High-mobility group (nonhistone chromosomal) protein 2 | S69272 | 0.39 | Cytoplasmic antiproteinase | ||||||
| AB001325 | 0.282 | AQP3 Aquaporin 3 | M55621 | 0.4 | MGAT1 N-acetylglucosaminyltransferase I | ||||||
| M17733 | 0.29 | Thymosin beta-4 mRNA | X04085 | 0.415 | CAT Catalase | ||||||
| X62466 | 0.304 | CDW52 CDW52 antigen (CAMPATH-1 antigen) | X05276 | 0.427 | TPM4 Tropomyosin 4 (fibroblast) | ||||||
| X95404 | 0.304 | CFL1 Cofilin 1 (non-muscle) | U20240 | 0.461 | CEBPG CCAAT/enhancer binding protein (C/EBP), gamma | ||||||
| M69181 | 0.321 | Nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds | LYL1 high NO-ONCOGENE_GROUP low | 0 | |||||||
| M75126 | 0.322 | HK1 Hexokinase 1 | M14745 | 0.015 | BCL2 B cell lymphoma protein 2 | ||||||
| M38591 | 0.358 | S100A10 S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)) | X72889 | 0.102 | Transcriptional activator hSNF2a | ||||||
| M10277 | 0.385 | ACTB Actin, beta | M22638 | 0.131 | LYL-1 protein gene | ||||||
| U18009 | 0.403 | Chromosome 17q21 mRNA clone LF113 | Z68228 | 0.139 | JUP Junction plakoglobin | ||||||
| M12886 | 0.434 | TCRB T-cell receptor, beta cluster | M91438 | 0.187 | Kazal-type serine proteinase (HUSI-II) gene | ||||||
| X17567 | 0.442 | SNRPB Small nuclear ribonucleoprotein polypeptides B and B1 | X02596 | 0.217 | Bcr (breakpoint cluster region) gene in Philadelphia chromosome | ||||||
| J04173 | 0.457 | PGAM1 Phosphoglycerate mutase 1 (brain) | D17793 | 0.256 | DDH1 Dihydrodiol dehydrogenase | ||||||
| TAL high NO-ONCOGENE_GROUP low | P | U67963 | 0.27 | Lysophospholipase homolog (HU-K5) mRNA | |||||||
| M12959 | 0.016 | TCRA T cell receptor alpha-chain | M13241 | 0.302 | N-MYC PROTO-ONCOGENE PROTEIN | ||||||
| K02777 | 0.177 | T-cell receptor active alpha-chain mRNA from Jurkat cell line | U78027 | 0.319 | Description for U78027 (clusters Hs.3136 Hs.15593 Hs.85020) not available | ||||||
| D43968 | 0.271 | CBFA2 Proto-oncogene AML1 {alternative products} | Y12670 | 0.324 | LEPR Leptin receptor | ||||||
| U09770 | 0.287 | Cysteine-rich heart protein (hCRHP) mRNA | U51903 | 0.399 | RasGAP-related protein (IQGAP2) mRNA | ||||||
| M16336 | 0.44 | CD2 CD2 antigen (p50), sheep red blood cell receptor | U60975 | 0.4143 | Hybrid receptor gp250 precursor mRNA | ||||||
| S77763 | 0.44 | NF-E2 protein (NF-E2) mRNA | |||||||||
| X04085 | 0.468 | CAT Catalase | |||||||||
| HG987-HT987 | 0.485 | Mac25 |