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Ferrando et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell. 2002 Feb; 1(1):75-87. PMID: 12086890 Scan IDs, sample details, and scaling factors Clinical And Lab Data Table (Tab Delimited) HOX11 Nearest Neighbors, 27 selected cases (HTML) HOX11 Nearest Neighbors, 27 selected cases (Excel) HOX11 Nearest Neighbors, 39 samples (HTML) HOX11 Nearest Neighbors, 39 samples (Excel) LYL1 Nearest Neighbors, 27 selected cases (HTML) LYL1 Nearest Neighbors, 27 selected cases (Excel) LYL1 Nearest Neighbors, 39 samples (HTML) LYL1 Nearest Neighbors, 39 samples (Excel) Permutation test analysis (HTML) Permutation test analysis (Excel) TAL1 Nearest Neighbor, 27 selected cases (HTML) TAL1 Nearest Neighbor, 27 selected cases (Excel) TAL1 Nearest Neighbor, 39 samples (HTML) TAL1 Nearest Neighbor, 39 samples (Excel) Fluorescence intensities Raw CEL files, part 1 (41MB) Fluorescence intensities Raw CEL files, part 2 (43MB) (right-click on the links above and select "save link as") |
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Langenau DM, Traver D, Ferrando AA, Kutok JL, Aster JC, Kanki JP, Lin S, Prochownik E, Trede NS, Zon LI, Look AT. Myc-induced T-cell leukemia in transgenic zebrafish. Science 299:887-890, 2003. Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: Dominance of HOX dysregulation. Blood 102:262-268, 2003. Morris JP, IV, Berghmans S, Zahrieh D, Neuberg DS, Kanki JP, Look AT. Zebrafish sperm cryopreservation with N,N-Dimethylacetamide. BioTechniques (In press, 2003). Bennett CM, Hsu K and Look AT. Myeloid Leukemia, myelodysplasia, and myeloproliferative disease in children. In: Nathan DG, Orkin SH, Ginsburg D, Look AT, Eds. Hematology of Infancy and Childhood, 6th Ed, Vol.1-2. W.B. Saunders, Philadelphia, PA. pp. 1167-1209, 2003. Berman J, Hsu K, Look AT. Zebrafish as a model organism for blood diseases. British J. Hematol. (In press, 2003). Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT, Knock-down of Zebrafish Fancd2 Causes Developmental Abnormalities via p53-Dependent Apoptosis. Developmental Cell (In press, 2003). |
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Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT. Gene expression signatures define novel oncogenic pathways in T-cell acute lymphoblastic leukemia. Cancer Cell 1:75- 87, 2002. Liu TX, Zhou Y, Kanki JP, Deng M, Rhodes J, Yang HW, Sheng XM, Zon LI, Look AT. Evolutionary conservation of zebrafish linkage group 14 with frequently deleted human chromosome 5 in myeloid malignancies. Proc. Natl. Acad. Sci. USA 99:6136-6141, 2002. Langenau DM, PalomeroT, Kanki JP, Ferrando AA, Zhou Y, Zon LI, and Look AT. Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio). Mech. Dev. 117:343-348, 2002. Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT. Slug, a highly conserved zinc-finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2:279-288, 2002. Look AT. A leukemogenic twist for GATA1. Nat. Genetics 32:83-84, 2002. |
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Brodeur GM, Look AT, Shimada H, Hamilton VM, Maris JM, Hann HW, Leclerc JM, Bernstein M, Brisson LC, Brossard J, Lemieux B, Tuchman M, Woods WG. Biological aspects of neuroblastomas identified by mass screening in Quebec. Med. Pediatr. Oncol. 36:157-59, 2001. Seidel MG and Look AT. E2A-HLF usurps control of evolutionarily conserved survival pathways. Oncogene 20:5718-5725, 2001. Hsu K, Kanki JP and Look AT. Zebrafish myelopoiesis and blood cell development. Curr. Opin. Hematol. 81:245-251, 2001. Daniels,J.L.; Olshan,A.F.; Teschke,K.; Hertz-Picciotto,I.; Savitz,D.A.; Blatt,J.; Bondy,M.L.; Neglia,J.P.; Pollock,B.H.; Cohn,S.L.; Look,A.T.; Seeger,R.C.; Castleberry,R.P. Residential pesticide exposure and neuroblastoma. Epidemiol. 12:20-27, 2001. Shinjyo T, Kuribara R, Inukai T, Hosoi H, Kinoshita T, Miyajima A, Houghton PJ, Look AT, Ozawa K, Inaba T. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol. Cell. Biol. 21(3):854-64, 2001. Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S, Look AT. The E2A-HLF Oncoprotein Activates Groucho-Related Genes and Suppresses Runx1. Mol. Cell. Biol. (In press). Bennett CM, Kanki JP, Rhodes J, Paw BH, Kieran MW, Langenau DM, Delahaye-Brown A, Liu TX, Zon LI, Fleming MD, Look AT (2001). Myelopoiesis in the zebrafish, Danio rerio. Blood (In press). |
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Yang Q, Olshan AF, Bondy ML, Shah NR, Pollock BH, Seeger RC, Look AT, Cohn SL. Parental smoking and alcohol consumption and risk of neuroblastoma. Cancer Epidemiology 9:967-972, 2000. Ferrando AA and Look AT. Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Seminars Hematol. 37:381-395, 2000. Look AT. Aberrant control of cell fate in the leukemias and lymphomas. In: Zon LI (ed). Hematopoiesis: A Developmental Approach. Oxford University Press, New York, NY, pp. 672-688, 2000. Choi SH, Kong X, Taki T, Tuschida Y, Kawaguchi H, Kato H, Hanada R, Look AT, Hayashi Y. Reduced or absent expression and codon 201Gly/Arg polymorphism of DCC gene in rhabdomyosarcoma and Ewing's sarcoma/PNET family. Intl. J. Mol. Med. 6:463-467, 2000. |
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Meyerhardt JA, Caca K, Ekstrand BC, Hu G, Legnauer C, Banavali S, u G, Sitwala KVLook AT, Fearon ER. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ. 10(1):35-42, 1999. Kurosawa H, Goi K, Inukai T, Inaba T, Chang K-S, Shinjyo T, Rakestraw KM, Naeve CW, Look AT. Two candidate downstream target genes for E2A-HLF. Blood 93(1):321-332, 1999. Hitzler JK, Soares HD, Drolet DW, Inaba T, O'Connel S, Rosenfeld MG, Morgan JI, Look AT. Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice. Brain Research 820:1-11, 1999. Bodner SM, Naeve CW, Rakestraw KM, Jones BG, Valentine VA, Valentine MB, Luthardt FW, Willman CL, Raimondi SC, Downing JR, Roussel MF, Sherr CJ, Look AT. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Gene 229:223-228, 1999. Kuribara R, Kinoshita T, Miyajima A, Sinjyo T, Yoshihara T, Inukai T, Ozawa K, Look AT, Inaba T. Two distinct signal transduction pathways, Ras/NFIL3(E4BP4) and Bcl-xL/caspase-3, regulate the IL-3-mediated survival of murine pro-B lymphocytes. Mol. Cell. Biol. 19(4):2754-62, 1999. Kong XT, Valentine VA, Rowe ST, Valentine MB, Ragsdale ST, Jones BG, Wilkinson DA, Brodeur GM, Cohn SL, Look AT. Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines. Neoplasia 1:80-89, 1999. Shuster JJ, Camitta BM, Pullen J, Borowitz MJ, Carroll AJ, Look AT, Mahoney DH, Mahmoud H, Lauer SJ, Land VJ. Identification of newly diagnosed children with acute lymphocytic leukemia at high risk for relapse. Cancer Research Therapy and Control 9:101-107, 1999. Komuro H, Valentine MB, Rubnitz, JE, Saito M, Raimondi SC, Carroll AJ, Yi T, Sherr CJ, Look AT. p27KIP1 deletions in childhood acute lymphoblastic leukemia. Neoplasia 1:253-261, 1999. Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT. SLUG, a ces-1-related zinc-finger transcription factor gene with antiapoptotic activity, Is a downstream target of the E2A-HLF oncoprotein. Molecular Cell 4:343-352, 1999. Olshan AF, Smith J, Cook MN, Grufferman S, Pollock BH, Stram DO, Seeger RC, Look AT, Cohn SL, Castleberry RP, Bondy ML. Hormone and fertility drug use and the risk of neuroblastoma: A report from the Children's Cancer Group and the Pediatric Oncology Group. Am. J. Epidemiology 150:930-938, 1999. |
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Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA. Inactivating mutations in an SH2 domain-encoding gene in x-linked lymphoproliferative syndrome. Proc.Natl.Acad.Sci. USA 95(23):13765-13770, 1998. Komuro H, Valentine MB, Rowe ST, Kidd VJ, Cohn SL, Look AT. Fluorescence in situ hybridization analysis of chromosome 1p36 deletions in human MYCN amplified neuroblastomas. J Pediatr. Surg. 33(11):1695-1698, 1998. Shuster JJ, Wacker P, Pullen J, Humbert J, Land VJ, Mahoney, Jr., DH, Lauer S, Look AT, Borowitz MJ, Carroll AJ, Camitta B. Prognostic significance of sex in childhood B-precursor acute lymphoblastic leukemia: A Pediatric Oncology Group study. J. Clin. Oncol. 16(8):2854-2863, 1998. Inukai T, Inaba T, Ikushima S, Look AT. The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF. Mol. Cell. Biol. 18(10):6035-6043, 1998. Altura RA, Inukai T, Ashmun RA, Zambetti GP, Roussel MF, Look AT. The chimeric E2A-HLF transcription factor abrogates p53-induced apoptosis in myeloid leukemia cells. Blood 92:1397-1405, 1998. Ohi R, Foektistova A, McCann S, Valentine V, Look AT, Lipsick JS, Gould KL. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Mol. Cell. Biol. 18(7):4097-4108, 1998. Whitehead VM, Vuchich M-J, Carroll AJ, Lauer SJ, Mahoney DH, Shuster JJ, Payment C, Koch PA, Akabutu JJ, Bowen T, Kamen BA, Ravindranath Y, Emami A, Look AT, Beardsley GP, Pullen DJ, Camitta B. Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: A Pediatric Oncology Group study. Leukemia and Lymphoma 31:507-519, 1998. Katzenstein HM, Bowman LC, Brodeur GM, Thorner PS, Joshi VV, Smith EI, Look AT, Rowe ST, Nash MB, Holbrook T, Alvarado C, Rao PV, Castleberry RP, Cohn SL. The prognostic significance of age, MYCN oncogene amplification, tumor cell ploidy, and histology in 110 infants with stage D(S) neuroblastoma: The Pediatric Oncology Group experience. J Clin Oncol. 16(6):2007-2017, 1998. Sublett JE, Entrekin RE, Look AT, Reardon DA. Chromosomal localization of the human smoothened gene (SMOH) to 7q32.3 by fluorescence in situ hybridization and radiation hybrid mapping. Genomics 50:112-114, 1998. |
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