Research Interest
I am working on the regulation of the number, the nucleation and the initiation of cytoplasmic microtubules during the cell cycle in the budding yeast Saccharomyces cerevisiae. These cytoplasmic microtubules are nucleated from the spindle pole body (centrosome of budding yeast) and are important for the position and the orientation of the spindle along the mother-cell axis. The correct position and orientation of the spindle allows a correct distribution of the chromosome set between
the mother and the daughter cell. We are using fluorescence microscopy, FRAP, tomography-EM, biochemistry and genetics to answer these questions.
Education
| 2003–present | Postdoctoral fellowship at Dana-Farber Cancer Institute, group of David Pellman |
| 2003 | PhD of genetics at CEA Fontenay aux Roses. Group of Serge Boiteux. Paris, France |
| 1999 | DEA of genetics (one year before PhD) in Libri and Sainsard-Chanet Groups, Institut de Genetique Cellulaire et Moleculaire, Orsay Universite Paris XI. Paris, France.
Also in Boiteux group, CEA Fontenay aux Roses. Paris, France |
| 1998 | Maitrise (bachelor) of genetics. Universite d'Angers France |
Selected publications
- Yoshida S, Guillet M, & Pellman D. MEN signaling: daughter bound pole must escape her mother to be fully active. Dev Cell. (2005), 9(2): 168–170
- Boiteux S. and Guillet M. Abasic sites in DNA : repair and biological consequences in S.cerevisiae. DNA repair (2004), 3: 1–12
- Guillet M, and Boiteux S. Origin of endogenous DNA abasic sites in Saccharomyces cerevisiae. Mol Cell Biol (2003), 23: 8386–8394
- Guillet M, and Boiteux S. Endogenous DNA Abasic Sites Cause Cell Death in Absence of Apn1, Apn2, and Rad1–Rad10 in Saccharomyces cerevisiae. EMBO J (2002), 21: 2833–2841
- Guillet, M. and Boiteux, S. (2002), Endogenous DNA Abasic Sites Cause Cell Death in Absence of Apn1, Apn2, and Rad1-Rad10 in Saccharomyces cerevisiae, EMBO J, 21, 2833-2841.
