Masayuki Nitta, MD PhD

masayuki_nitta@dfci.harvard.edu

Education

2004–present	Postdoctoral fellow. Pellman Lab, Dana-Farber Cancer Institute
1998–2002	PhD, Graduate School of Medical Sciences, Kumamoto University. Kumamoto, Japan
1994–1998	Residency, Kumamoto University School of Medicine. Kumamoto, Japan
1988–1994	MD, Kumamoto University School of Medicine. Kumamoto, Japan

Selected publications

• Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT & Pellman D. Cytokinesis failure, generating aneuploidy, promotes tumorigenesis in p53-null cells. Nature 2005; 437(7061):1043–7
• Bartholomeusz C, Itamochi H, Nitta M, Saya H, Ginsberg MH, & Ueno NT. Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15. Oncogene 2005 Sep 19
• Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y, Nakao M, & Saya H. Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria. J Biol Chem 2005; 280(19):19166–76
• Nitta M, Kobayashi O, Honda S, Hirota T, Kuninaka S, Marumoto T, Ushio Y, & Saya H. Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents. Oncogene 2004; 23(39):6548–58.
• Sudo T, Nitta M, Saya H, & Ueno NT. Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint. Cancer Res 2004; 64(7):2502–8
• Honda S, Marumoto T, Hirota T, Nitta M, Arima Y, Ogawa M, & Saya H. Activation of m-calpain is required for chromosome alignment on the metaphase plate during mitosis. J Biol Chem 2004; 279(11):10615–23
• Marumoto T, Honda S, Hara T, Nitta M, Hirota T, Kohmura E, & Saya H. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells. J Biol Chem 2003; 278(51):51786–95
• Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, & Saya H. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. Cell 2003; 114(5):585–98
• Nitta M, Tsuiki H, Arima Y, Harada K, Nishizaki T, Sasaki K, Mimori T, Ushio Y, & Saya H. Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability. Genes Cells 2002; 7(2):151–62
• Tsuiki H, Nitta M, Tada M, Inagaki M, Ushio Y, Saya H. Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines. Oncogene 2001; 20(4):420–9
• Tsuiki H, Nitta M, Furuya A, Hanai N, Fujiwara T, Inagaki M, Kochi M, Ushio Y, Saya. H, & Nakamura H. A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. J Cell Biochem 1999; 6(2):254–69