The Breast Cancer Genetics Laboratory at the Dana-Farber Cancer Institute, Harvard Medical School is dedicated to the molecular analysis of human breast cancer. Human breast cancer arises as the result of a series of genetic changes.

This laboratory is focusing on identifying differences between normal and cancerous breast tissue using various technologies, determining their consequences and utilizing them to improve the clinical management of breast cancer patients.

Our lab has created, in collaboration with the Cancer Genome Anatomy Project and the National Center for Biotechology Information, the first and largest public database for gene expression in humans (Lal et al. 1999). Serial analysis of gene expression (SAGE) transcript profiles from more than 100 representative tumors, cell lines and normal tissues are accessed at: www.cgap.nci.nih.gov/SAGE/.

We are also part of the SPORE (Specialized Programs of Research Excellence) in Breast Cancer at DF/HCC (Dana-Farber/Harvard Cancer Center).