Garraway LA, Widlund HR, Rubin MA, Getz GA, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. 2005 Nature. Download pdf.

Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frohling S, Dohner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005 Apr; 7(4):387-397. Download pdf.

Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, Timothy J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia via regulation of apoptotic and Hif1-dependent pathways. Nature Medicine 2004 Jun;10(6):594-601. Download pdf.

Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR*, Johnson BE*, Meyerson M* EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy. Science 2004 Jun 4;304(5676):1497-500. *co-corresponding authors. Download pdf.

Zhao X, Li C, Paez JG, Chin K, Jänne PA, Chen TH, Girard L, Minna J, Christiani D, Leo C, Gray JW, Sellers WR and Meyerson M. An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Research 2004 May 1;64(9):3060-71. Download pdf.

Rubin MA, Varambally S, Beroukhim R, Tomlins SA, Rhodes DR, Paris PL, Hofer MD, Storz-Schweizer M, Kuefer R, Fletcher JA, His, B-L., Byrne JA, Pienta KJ, Collins C, Sellers WR, and Chinnaiyan AM. Overexpression, Amplification and Androgen-regulation of TPD52 in Prostate Cancer. Cancer Research 2004. Jun 1;64(11):3814-22. Download pdf.

Paez JG, Lin M, Beroukhim R, Lee JC, Zhao X, Richter DJ, Gabriel S, Herman P, Sasaki H, Altshuler D, Li C, Meyerson M, Sellers WR. Genome coverage and sequence fidelity of f29 polymerase-based multiple-strand displacement whole-genome amplification. Nucleic Acids Research 2004 May 18;32(9):e71. Download pdf.

Jiang J, J. Paez JG1, Lee JC, BO R, Stone RM, DeAngelo DJ, Galinsky I, Wolpin BM,, Jonasova A, Herman P, Fox EA, Boggon TJ, Eck MJ, Weisberg E, Griffin JD, Gilliland DG, Meyerson M, Sellers WR. Identification and Characterization of a Novel Activating Mutation of the FLT3 tyrosine kinase in AML. Blood 2004 (in press). Download pdf.

Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K. Molecular characterization of epithelial-stromal cell interactions in breast tumorigenesis. Cancer Cell 2004 (in press). Download pdf.

Hsieh, A.C., R. Bo, J. Manola, F. Vazquez, O. Bare, A. Khvorova, S. Scaringe, W. R. Sellers. 2004. A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: Determinants of gene silencing for use in cell-based screens. Nucleic Acid Res Feb 09;32(3):893-901. Download pdf.

Lin, M. L.J. Wei, W.R. Sellers, M. Lieberfarb, W.H. Wong, C. Li. 2003. dChipSNP: Significance curve and clustering of SNP-array-based loss-of-heterozygosity data. Bioinformatics May 22;20(8):1233-40. Download pdf.

Kau, T.R., F. Schroeder, S. Ramaswamy, C.L. Wojciechowski, J.J. Zhao, T.M. Roberts, J. Clardy. W.R. Sellers, P.A. Silver. 2003 A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell Dec;4(6):463-76. Download pdf.

Brugarolas, J.B., F. Vazquez, A. Reddy, W.R. Sellers, W.G.Kaelin, Jr. 2003. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell. 4: 147-158. Download pdf.

Lieberfarb, M.E., M. Lin, M. Lechpammer, C. Li, D. M. Tanenbaum, P.G. Febbo, R. L. Wright, J. Shim, P.W. Kantoff, M. Loda, M. Meyerson, W. R. Sellers 2003 Genome-wide loss-of-heterozygosity analysis from laser-capture microdissected prostate cancer using SNP arrays and a novel bioinformatics platform Cancer Res 2003; 63. 4781-4785. Download pdf.

Majumder, P.K., J.J. Yeh, D.J. George, P.G. Febbo, J. Kum, X. Que, R. Bikoff, H. Ma, P.W. Kantoff, T.R. Golub,M. Loda, W. R. Sellers 2003 Prostate intraepithelial neoplasia induced by prostate restricted Akt activation – the MPAKT model. PNAS 100:7841-7846. Download pdf.

Ramaswamy, S., N. Nakamura, I. Sansal , L. Bergeon and W. R. Sellers 2002. A Novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer Cell 2(1):81-91. Download pdf / Expression data.

Singh, D., P.G. Febbo, K. Ross, D. G. Jackson, J. anola, C. Ladd, P. Tamayo, A.A. Renshaw, A.V. D'Amico, J.P. Richie, E. S. Lander, M. Loda, P.W. Kantoff, T.R. Golub and W.R. Sellers. 2002. Gene Expression Correlates of Clinical Prostate Cancer Behavior. Cancer Cell. 1: 1-7. Download pdf / Supplemental and Raw Data.

DiRenzo, J., S. Signoretti, N. Nakamura, R. Rivera-Gonzalez,W.R. Sellers, M. Loda and M. Brown. 2002. Growth factor requirements and basal phenotype of an ommortalozed mammary epithelial cell line. Cancer Res. 62: 89-98. Download pdf.

Vazquez, F., S.R. Grossman, Y. Takahashi, M. Rokas, N. Nakamura and W. R. Sellers. 2001. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem. 276(52):48627-48630. Download pdf.

Gesbert, F., W.R.Sellers, S. Signoretti, M. Loda, J.D. Griffin. 2000. BCR/ABL Regulates Expression of the Cyclin-dependent Kinase Inhibitor p27Kip1 through the Phosphotidylinositol 3-Kinase/AKT Pathway. J. Biol. Chem. 275: 39223-39230. Download pdf.

Miyake, S., W.R. Sellers, M. Safran, W. Li, S.R. Grossman,J. Gan, J.A. DeCaprio, P.D. Adams and W. G.Kaelin Jr. 2000. Cells degrade a novel inhibitor of differentiation with E1A like properties upon exiting the cell cycle. Mol.Cell.Biol. 20(23): 8889-8902 Download pdf.

Nakamura, N., S. Ramaswamy, F. Vazquez, S. Signoretti, M. Loda and W.R. Sellers. 2000. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol. 20(23): 8969-8982 Download pdf.

Vazquez, F., S. Ramaswamy, N. Nakamura and W. R. Sellers. 2000. Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol. 20(14): 5010-8.Download pdf.

McMenamin, M. E., P. Soung, S. Perera, I. Kaplan, M. Loda and W. R. Sellers. 1999. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res. 59: 4291-6. Download pdf.

Ramaswamy, S., N. Nakamura, F. Vazquez, D. B. Batt, S. Perera, T. M. Roberts and W. R. Sellers. 1999. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A. 96: 2110-2115. Download pdf.

Sellers, W. R., B. G. Novitch, S. Miyake, A. Heith, G. A. Otterson, F. J. Kaye, A. B. Lassar and W. G. Kaelin, Jr. 1998. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes & Development. 12: 95-106. Download pdf.

Sellers, W. R., J. W. Rodgers and W. G. Kaelin, Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proceedings of the National Academy of Sciences of the United States of America. 92: 11544-8. Download pdf.

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